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KMID : 0614620090530010053
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Korean Journal of Gastroenterology
2009 Volume.53 No. 1 p.53 ~ p.56
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A Case of Pseudomembranous Colitis Associated with Rifampicin Therapy in a Patient with Rectal Cancer and Gastrointestinal Tuberculosis
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Choi Yong-Jun
Kim Hyung-Gil
Shin Yong-Woon
Kim Young-Soo
Son Dong-Wook
Kim Chul-Hyun
Joo Woo-Chul
Choi Yun-Ah
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Abstract
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Pseudomembranous colitis (PMC) is known to be associated with the administration of antibiotics which alter normal gastrointestinal flora and allow overgrowth of Clostridium difficile. Most cases of rifampicin-induced PMC are seen in patients with pulmonary tuberculosis, but not with gastrointestinal tuberculosis. We report a case of PMC associated with rifampicin therapy in a patient with gastrointestinal tuberculosis. A 65-year-old female patient with rectal cancer and gastrointestinal tuberculosis was admitted due to abdominal pain and diarrhea. She was treated with anti-tuberculosis agents containing rifampicin. On colonoscopic examination, mucoid exudates and yellowish plaque lesions were observed. Anti-tuberculosis agents were stopped, and the patient was treated with metronidazole. Symptoms were relieved and did not recur when all the anti-tuberculosis agents except rifampicin were started again. When a patient complains of abdominal pain or diarrhea while taking rifampicin, the physician should consider the possibility of rifampicin-associated PMC.
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KEYWORD
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Gastrointestinal tuberculosis, Rectal cancer, Rifampicin, Pseudomembranous colitis
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